Ante-post favourite Defi Du Seuil will not run in the Unibet Greatwood Handicap Hurdle at Cheltenham on Sunday.
The classy four-year-old is unbeaten in seven races over hurdles but will not be asked to make his seasonal reappearance in the big-field Grade Three handicap at the weekend.
Last season's Triumph Hurdle winner, trained by Philip Hobbs, will instead run in the Coral Hurdle at Ascot on Saturday week.
Owner JP McManus' racing manager Frank Berry said: "There's another option at Ascot. Yesterday I said he was an intended runner and he was, but we've looked at everything - the weight and him being a four-year-old - and it looks like Ascot will be better for him.
"It will be the two-mile-three race, the Ascot (Coral) Hurdle."