The son of Frankel led home a one-two-three for the Aidan O'Brien stable as he ran his rivals ragged in the hands of the trainer's son Donnacha.
Nelson (11-2) opened his account over the course and distance in similar fashion three weeks earlier and the tactics worked again.
Galloping on strongly, Nelson came home clear from Kew Gardens, with stable first choice Delano Roosevelt only third.
The winning rider said: "He kept galloping all the way to the line. It was a nice performance.
"I thought I'd gone a nice, even pace. I quickened from the bend and thought it would take a good one to get me."
Nelson was cut to 16-1 from 33-1 for the Investec Derby with Paddy Power. RaceBets go 25-1 from 33-1.