John Gosden's filly has carried all before her this season and is attempting to win her fifth Group One in succession.
Numerically Aidan O'Brien fields the strongest opposition after saddling the first three home last year.
Order Of St George, Capri, Seventh Heaven, Idaho and Winter all line up for Ballydoyle with Highland Reel and Cliffs Of Moher skipping the race.
Sir Michael Stoute's Ulysses, second to Enable in the King George but winner of the Eclipse and Juddmonte International either side of that, will attempt to give his trainer a second Arc.
The main French challenge is expected to come from Brametot, winner of the French Guineas and Derby, and Zarak.
Andre Fabre runs Cloth Of Stars, Plumatic and Doha Dream while German interest rests with Dschingis Secret, winner of the Prix Foy, and Iquitos.
Satono Diamond, who will have the assistance of his pacemaker Satono Noblesse, lines up for Japan.
The field is completed by One Foot In Heaven and Silverwave with the draw taking place this evening.